GPR40 agonist K-757

Chemical Structure : GPR40 agonist K-757

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货号: PC-25130Not For Human Use, Lab Use Only.

GPR40 agonist K-757 is a potent, selective GPR40 (FFA1) agonist with EC50 of 2.1 nM (hGPR40).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote

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生物&药学活性

GPR40 agonist K-757 is a potent, selective GPR40 (FFA1) agonist with EC50 of 2.1 nM (hGPR40).
K-757 is selective against panel of 80 enzymes, receptors, and ion channels.
K-757 (10 mg/kg) elicited GLP-1 secretion in crypt cultures derived from wild-type mice but not from GPR40 knockout mice, induced secretion of both GLP-1 and PYY in human crypts.

物理化学性质&存储条件

分子量	541.71
分子式	C32H48NO4P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	((S)-2-Cyclopropyl-2-(3-((1-(2-(4,4-dimethylpentyl)-5-methoxyphenyl)piperidin-4-yl)methoxy)phenyl)ethyl)(methyl)phosphinic Acid

参考文献

1. Moyes CR, et al. J Med Chem. 2025 Jul 24. doi: 10.1021/acs.jmedchem.5c01030.