GNTbm-38 | Class l HDAC inhibitor, Epigenetic modulator

Chemical Structure : GNTbm-38

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GNTbm-38 (GNTbm38)

货号: PC-28463Not For Human Use, Lab Use Only.

GNTbm-38 is a selective class I HDAC inhibitor and epigenetic immunomodulator, significantly increases anti-tumoral responses of regorafenib in CT26 tumor model.

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生物&药学活性

GNTbm-38 is a selective class I HDAC inhibitor and epigenetic immunomodulator, significantly increases anti-tumoral responses of regorafenib in CT26 tumor model.
GNTbm-38 induces histone 3 acetylation accumulation in human colorectal adenocarcinoma SW48 cells.
GNTbm-38 shows average growth inhibition (GI50) value of 1.46 μM in NCI-60 human cancer cell lines.
GNTbm-38 exhibited excellent cell growth-inhibiting activity against CCRF-CEM, HCT 116, SW-620, TK-10, SF-539, and OVCAR-8, etc.
GNTbm-38 combined with regorafenib regimen possesses potent TME reprogramming activity to boost the tumor response rate in CT26 tumor-bearing mice.

物理化学性质&存储条件

分子量	372.43
分子式	C22H20N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-N-(2-aminophenyl)-4-(4-(pyridin-3-yl)but-3-enamido)benzamide

参考文献

1. Chen CN, et al. Mol Cancer Ther. 2026 Oct 7. doi: 10.1158/1535-7163.MCT-25-1441.

GNTbm-38 (GNTbm38)

生物&药学活性

物理化学性质&存储条件

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GNTbm-38 (GNTbm38)

生物&药学活性

物理化学性质&存储条件

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