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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-p97/VCP-GND-135
GND-135

Chemical Structure : GND-135

CAS No.: 3069322-03-5

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GND-135 (GND135)

货号: PC-27077Not For Human Use, Lab Use Only.

GND-135 is a potent, cell-permeable, and orally bioavailable inhibitor of VCP/p97 AAA ATPase with IC50 of <10 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GND-135 is a potent, cell-permeable, and orally bioavailable inhibitor of VCP/p97 AAA ATPase with IC50 of <10 nM.
GND-135 eliminates PDE6 cross-reactivity while maintaining VCP/p97 potency.
GND-135 has com­parable in vivo efficacy com­pared to CB-5083.

物理化学性质&存储条件

分子量 536.64
分子式 C31H32N6O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-(benzylamino)-2-methyl-1-(2-morpholino-2-oxoethyl)-1H-pyrrolo[2,3-b]pyridin-6-yl)-2-methyl-1H-indole-4-carboxamide

参考文献

1. Crawford J, et al. IUCrJ. 2026 Jul 1. doi: 10.1107/S2052252526004604.

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