GMX-1777 chloride (Teglarinad) | NAMPT inhibitor | Probechem Biochemicals

Chemical Structure : GMX-1777 chloride

CAS No.: 432037-57-5

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GMX-1777 chloride (GMX1777 chloride, Teglarinad, EB-1627)

货号: PC-60007Not For Human Use, Lab Use Only.

GMX-1777 chloride (Teglarinad) is the water-soluble prodrug of GMX-1778 (CHS-828), which is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme NAMPT with IC50 of <20 nM.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

GMX-1777 chloride (Teglarinad) is the water-soluble prodrug of GMX-1778 (CHS-828), which is a potent and specific inhibitor of the NAD(+) biosynthesis enzyme NAMPT with IC50 of <20 nM.
GMX-1777 shows anticancer activity in clinical trials, can be used in combination with other drugs to treat malignant melanoma.

物理化学性质&存储条件

分子量	672.601
分子式	C30H43Cl2N5O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	100 mM in H2O
Chemical Name/SMILES	[4-[[N'-[6-(4-chlorophenoxy)hexyl]-N-cyanocarbamimidoyl]amino]pyridin-1-ium-1-yl]methyl 2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl carbonate chloride

参考文献

1. Watson M, et al. Mol Cell Biol. 2009 Nov;29(21):5872-88.

2. Beauparlant P, et al. Anticancer Drugs. 2009 Jun;20(5):346-54.

3. Kato H, et al. Clin Cancer Res. 2010 Feb 1;16(3):898-911.

4. Chan M, et al. Cancer Res. 2014 Nov 1;74(21):5948-54.

GMX-1777 chloride (GMX1777 chloride, Teglarinad, EB-1627)

生物&药学活性

物理化学性质&存储条件

参考文献

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GMX-1777 chloride (GMX1777 chloride, Teglarinad, EB-1627)

生物&药学活性

物理化学性质&存储条件

参考文献

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