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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Androgen Receptor (AR)-GLPG0492
GLPG0492

Chemical Structure : GLPG0492

CAS No.: 1215085-92-9

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GLPG0492 (GLPG-0492)

货号: PC-45421Not For Human Use, Lab Use Only.

GLPG0492 (GLPG-0492) is an orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM.

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5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

GLPG0492 (GLPG-0492) is an orally active, non-steroidal selective androgen receptor modulator (SARM) with in vitro potency of 13 nM.
GLPG0492 exhibits anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate in a classical model of orchidectomized rat.
GLPG0492 shows a potential treatment for Duchenne muscular dystrophy (DMD).

物理化学性质&存储条件

分子量 389.328
分子式 C19H14F3N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Benzonitrile, 4-[(4S)-4-(hydroxymethyl)-3-methyl-2,5-dioxo-4-phenyl-1-imidazolidinyl]-2-(trifluoromethyl)-

参考文献

1. Nique F, et al. J Med Chem. 2012 Oct 11;55(19):8236-47.

2. Cozzoli A, et al. Pharmacol Res. 2013 Jun;72:9-24.

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