GLPG0259 | MAPKAPK5 inhibitor | Probechem Biochemicals

Chemical Structure : GLPG0259

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GLPG0259 (GLPG-0259)

货号: PC-24763Not For Human Use, Lab Use Only.

GLPG0259 is a potent, specific, ATP-competitive and orally bioavailable mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5, PRAK, MK5) inhibitor.

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100 mg		Get quote

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生物&药学活性

GLPG0259 is a potent, specific, ATP-competitive and orally bioavailable mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5, PRAK, MK5) inhibitor.
GLPG0259 reduces the release of several mediators of inflammation and bone degradation, such as MMP1, MMP13, TNF, and IL6.
GLPG0259 reduces paw inflammation as well as bone destruction in the mouse collagen-induced arthritis (CIA) model of human RA at a dose of 1 mg/kg and higher.

物理化学性质&存储条件

分子量	460.54
分子式	C24H28N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(8-((4-(4-(tert-Butyl)piperazin-1-yl)phenyl)amino)-[1,2,4]triazolo[1,5-a]pyrazin-5-yl)furan-2-carboxamide

参考文献

1. Namour F, et al. Drugs R D. 2012 Sep 1;12(3):141-63.

GLPG0259 (GLPG-0259)

生物&药学活性

物理化学性质&存储条件

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GLPG0259 (GLPG-0259)

生物&药学活性

物理化学性质&存储条件

参考文献

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