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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HBV-GLP-26
GLP-26

Chemical Structure : GLP-26

CAS No.: 2133017-36-2

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GLP-26 (GLP26)

货号: PC-35254Not For Human Use, Lab Use Only.

GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM.

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25 mg ￥3780 In stock
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纯度 & COA & 质检文件 纯度: 99.20% (HPLC) Select Batch:

生物&药学活性

GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM.
GLP26 is a potent inhibitor of cccDNA formation and HBeAg production against the mutant core T109I, demonstrates synergistic activity with ETV in the HepAD38 system, reducing HBV DNA replication.

物理化学性质&存储条件

分子量 373.36
分子式 C19H17F2N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(3,4-difluorophenyl)-1,3,5-trimethyl-4-(2-oxo-2-(prop-2-yn-1-ylamino)acetyl)-1H-pyrrole-2-carboxamide

参考文献

1. Nijampatnam B, et al. Curr Opin Chem Biol. 2019 Jun;50:73-79.

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