GLA-1-1

Chemical Structure : GLA-1-1

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货号: PC-26490Not For Human Use, Lab Use Only.

GLA-1-1 is a small-molecule agonist of large-conductance Ca²⁺-activated K⁺ (BK) channels with EC50 of 3.4 uM, induces autophagy flux by promoting autophagosome-lysosome fusion.

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生物&药学活性

GLA-1-1 is a small-molecule agonist of large-conductance Ca²⁺-activated K⁺ (BK) channels with EC50 of 3.4 uM, induces autophagy flux by promoting autophagosome-lysosome fusion.
GLA-1-1 reduces autofluorescent deposits and RPE abnormalities in Lamp2a-/- mice as detected by FAF, OCT, and confocal microscopy.
GLA-1-1 preserves retinal structure, RPE morphology, and visual function in Lamp2a-/- mice.
GLA-1-1 attenuates Lamp2a deficiency-associated lipid accumulation in the RPE and reduces Bruch's membrane thickening.
GLA-1-1 restores lysosome-dependent degradative abnormalities in CMA-deficient Lamp2a-/- mice.

物理化学性质&存储条件

分子量	341.41
分子式	C23H19NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3aR,4S,9bS)-4-(naphthalen-1-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-carboxylic acid

参考文献

1. Hilal Ahmad Mir, et al. bioRxiv [Preprint]. 2026 Mar 23:2026.03.19.712761.

GLA-1-1

生物&药学活性

物理化学性质&存储条件

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GLA-1-1

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物理化学性质&存储条件

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