GL-V9

Chemical Structure : GL-V9

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货号: PC-24392Not For Human Use, Lab Use Only.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

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生物&药学活性

GL-V9 is synthetic flavonoid derivative that possess an antitumor effect, effectively promotes the degradation of YAP1, reduces YAP1 nuclear localization, and induces mitochondrial apoptosis in PDAC cells, also induce apoptosis of CML cells via MAPK signaling pathway.
GL-V9 induces mitochondrial-mediated apoptosis and G2/M cell cycle arrest in human hepatocellular carcinoma HepG2 cells.
GL-V9 significantly suppressed the expression and activity of MMP-2 and MMP-9.
GL-V9 ameliorates DSS-induced colitis against oxidative stress by up-regulating Trx-1 expression via activation of AMPK/FOXO3a pathway.
GL-V9 suppresses invasion and migration of human colorectal cancer cells by inhibiting PI3K/Akt and MMP-2/9 signaling.

物理化学性质&存储条件

分子量	409.48
分子式	C24H27NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4H-1-Benzopyran-4-one, 5-hydroxy-8-methoxy-2-phenyl-7-[4-(1-pyrrolidinyl)butoxy]-

参考文献

1. Li L, et al. Eur J Pharm Sci. 2011 Aug 17;43(5):393-9.

2. Zhao Y, et al. Oncotarget. 2015 Sep 22;6(28):26291-307.

3. Liu H, et al. Pharmaceuticals (Basel). 2024 Oct 10;17(10):1352.

GL-V9

生物&药学活性

物理化学性质&存储条件

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GL-V9

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物理化学性质&存储条件

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