GK730 | SARS-CoV-2 Mpro inhibitor | Probechem Biochemicals

Chemical Structure : GK730

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GK730 (GK-730)

货号: PC-26178Not For Human Use, Lab Use Only.

GK730 is a highly potent, specific SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 5.75 nM, weakly inhibits cathepsin L and does not inhibit cathepsin B.

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生物&药学活性

GK730 is a highly potent, specific SARS-CoV-2 main protease (Mpro) inhibitor with IC50 of 5.75 nM, weakly inhibits cathepsin L and does not inhibit cathepsin B.
GK730 demonstrated an EC50 value of 5.70 μM against a wild-type SARS-CoV-2 strain in Vero E6 cells and minimal cytotoxicity.

物理化学性质&存储条件

分子量	643.76
分子式	C31H41N5O8S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 2-((5S,8S,11S)-8-isobutyl-5-isopropyl-3,6,9-trioxo-11-(((S)-2-oxopyrrolidin-3-yl)methyl)-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oyl)thiazole-4-carboxylate

参考文献

1. Theodoropoulou MA, et al. Eur J Med Chem. 2026 Feb 5;303:118436.

GK730 (GK-730)

生物&药学活性

物理化学性质&存储条件

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GK730 (GK-730)

生物&药学活性

物理化学性质&存储条件

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