欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Others-Other Targets-GI-Y2
GI-Y2

Chemical Structure : GI-Y2

CAS No.: 1008710-58-4

加入收藏

GI-Y2 (GSDMD inhibitor Y2)

货号: PC-24520Not For Human Use, Lab Use Only.

GI-Y2 (GSDMD inhibitor Y2) is a specific small molecule inhibitor of Gasdermin D (GSDMD), directly interacts with the Arg10 residue of GSDMD (SPR KD=36.0 uM) and reduces the membrane binding of N‐terminal domain (GSDMD‐N).

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GI-Y2 (GSDMD inhibitor Y2) is a specific small molecule inhibitor of Gasdermin D (GSDMD), directly interacts with the Arg10 residue of GSDMD (SPR KD=36.0 uM) and reduces the membrane binding of N-terminal domain (GSDMD‐N).
GI-Y2 directly interacts with the Arg10 residue of GSDMD and reduces the membrane binding of GSDMD-N.
GI-Y2 inhibits the formation of atherosclerotic plaques by targeting GSDMD.
GI-Y2 reduces pyroptosis and macrophage infiltration in atherosclerosis.

物理化学性质&存储条件

分子量 386.38
分子式 C18H14N2O6S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((3-(4-carboxybenzyl)-2,4-dioxothiazolidin-5-yl)amino)benzoic acid

参考文献

1. Mei Y, et al. Br J Pharmacol. 2025 Mar 31. doi: 10.1111/bph.70040.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: