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首页-抗体药物偶连体和PROTACs-E3 Ligase Ligand-GH501
GH501

Chemical Structure : GH501

CAS No.:

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GH501

货号: PC-24401Not For Human Use, Lab Use Only.

GH501 is a small molecule inhibitor of Skp1-Skp2 interaction, may bind Skp1 and disrupts the physical interaction between Skp1 and S-phase kinase-associated protein 2 (Skp2) within the Skp1-Cullin1-F-box protein ubiquitin ligase complexes (SCF).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GH501 is a small molecule inhibitor of Skp1-Skp2 interaction, may bind Skp1 and disrupts the physical interaction between Skp1 and S-phase kinase-associated protein 2 (Skp2) within the Skp1-Cullin1-F-box protein ubiquitin ligase complexes (SCF).
GH501 affects multiple oncogenic signals in mCRPC cells, affects multiple oncogenic signals implicated in mCRPC progression, including p21, p27, β-catenin, cyclin D1, enhancer of zeste homolog 2 (EZH2), c-Myc, and survivin.
GH501 monotherapy inhibits the in vivo growth of mCRPC in multiple xenograft models.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Li X, et al. Br J Cancer. 2025 Apr 19. doi: 10.1038/s41416-025-02993-8.

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