GH501 | Skp1-Skp2 inhibitor | Probechem Biochemicals

Chemical Structure : GH501

加入收藏

GH501 (GCBH-110)

货号: PC-24401Not For Human Use, Lab Use Only.

GH501 is a small molecule inhibitor of Skp1-Skp2 interaction, may bind Skp1 and disrupts the physical interaction between Skp1 and S-phase kinase-associated protein 2 (Skp2) within the Skp1-Cullin1-F-box protein ubiquitin ligase complexes (SCF).

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

GH501 is a small molecule inhibitor of Skp1-Skp2 interaction, may bind Skp1 and disrupts the physical interaction between Skp1 and S-phase kinase-associated protein 2 (Skp2) within the Skp1-Cullin1-F-box protein ubiquitin ligase complexes (SCF).
GH501 affects multiple oncogenic signals in mCRPC cells, affects multiple oncogenic signals implicated in mCRPC progression, including p21, p27, β-catenin, cyclin D1, enhancer of zeste homolog 2 (EZH2), c-Myc, and survivin.
GH501 monotherapy inhibits the in vivo growth of mCRPC in multiple xenograft models.

物理化学性质&存储条件

分子量	605.79
分子式	C39H44FN3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-3-([1,1'-biphenyl]-4-yl)-2-((R)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanamido)-N-(2,2,6,6-tetramethylpiperidin-4-yl)propanamide

参考文献

1. Li X, et al. Br J Cancer. 2025 Apr 19. doi: 10.1038/s41416-025-02993-8.

GH501 (GCBH-110)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

GH501 (GCBH-110)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.