GFH647 (GFH-647)

Chemical Structure : GFH647

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货号: PC-28073Not For Human Use, Lab Use Only.

GFH647 (GFH-647) is a potent, selective, reversible BTK inhibitor, potently inhibits both wild-type BTK and the clinically relevant C481S mutant.

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生物&药学活性

GFH647 (GFH-647) is a potent, selective, reversible BTK inhibitor, potently inhibits both wild-type BTK and the clinically relevant C481S mutant.
GFH647 shows binding the catalytic ATP pocket in a Cys481-independent manner.
GFH647 demonstrates robust antitumor activity in xenograft models driven by either wild-type or C481S-mutant BTK.

物理化学性质&存储条件

分子量	482.95
分子式	C25H15D6ClN4O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-9-(2-chloro-4-phenoxybenzoyl)-2-((methoxy-d3)methyl)-2-(methyl-d3)-1,2,4,6-tetrahydro-3H-pyrrolo[3',2':5,6]pyrido[3,4-b]pyrazin-3-one

参考文献

1. Patent WO2022063101 A1 2022-03-31.

GFH647 (GFH-647)

生物&药学活性

物理化学性质&存储条件

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GFH647 (GFH-647)

生物&药学活性

物理化学性质&存储条件

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