GDC-0276 | NaV1.7 inhibitor | Probechem Biochemicals

Chemical Structure : GDC-0276

CAS No.: 1494581-70-2

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GDC-0276 (GDC 0276)

货号: PC-72192Not For Human Use, Lab Use Only.

GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

GDC-0276 (GDC 0276) is a highly potent, selective NaV1.7 inhibitor with IC50 of with binding Ki of 1.1 nM (hNaV1.7), cellular sodium influx IC50 of 49 nM.
GDC-0276 displays 18-fold selectivity over NaV1.5 (cellular sodium influx IC50=870 nM), as well as 26-1200-fold selectivity over NaV1.1/1.2/1.6 (potency measured by voltage clamp).
GDC-0276 showed a concentration dependent reduction in nociceptive events, with a EC50 of 1.7 μM in inherited erythromelalgia (IEM) mouse model.

物理化学性质&存储条件

分子量	462.58
分子式	C24H31FN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO (4.6 mg/mL)
Chemical Name/SMILES	4-((Adamantan-1-yl)methoxy)-N-(azetidin-1-ylsulfonyl)-5-cyclopropyl-2-fluorobenzamide

参考文献

1. Brian S Safina, et al. J Med Chem. 2021 Mar 25;64(6):2953-2966.

GDC-0276 (GDC 0276)

生物&药学活性

物理化学性质&存储条件

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GDC-0276 (GDC 0276)

生物&药学活性

物理化学性质&存储条件

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