G721-0377

Chemical Structure : G721-0377

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货号: PC-26082Not For Human Use, Lab Use Only.

G721-0377 is a next-generation small molecule inhibitor of chitinase-3 like-protein-1 (CHI3L1, YKL-40) with binding Kd of 45 uM.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

G721-0377 is a next-generation small molecule inhibitor of chitinase-3 like-protein-1 (CHI3L1, YKL-40) with binding Kd of 45 uM.
G721-0377 exhibited favorable pharmacokinetic properties, including improved solubility, balanced permeability, reduced microsomal clearance, and an enhanced cardiac safety margin.
G721-0377 reversed CHI3L1-induced astrocytic dysfunction, restoring amyloid uptake, lysosomal proteolysis and acidification, suppressing CHI3L1 and IL-6 secretion, and inhibiting NF-κB activation to levels comparable to a neutralizing anti-CHI3L1 antibody.

物理化学性质&存储条件

分子量	455.53
分子式	C22H25N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(2-((6-isobutyl-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl)thio)acetamido)benzamide

参考文献

1. Baljit Kaur, et al. bioRxiv [Preprint]. 2026 Jan 13:2026.01.13.699206.

G721-0377

生物&药学活性

物理化学性质&存储条件

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G721-0377

生物&药学活性

物理化学性质&存储条件

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