G243-1720

Chemical Structure : G243-1720

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货号: PC-25947Not For Human Use, Lab Use Only.

G243-1720 is a potent, specific anti-poxvirus inhibitor with broad activity in vitro and in vivo, blocks the formation of extracellular enveloped virions and cell-cell spread, affecting dimerization of protein OPG57 (F13).

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生物&药学活性

G243-1720 is a potent, specific anti-poxvirus inhibitor with broad activity in vitro and in vivo, blocks the formation of extracellular enveloped virions and cell-cell spread, affecting dimerization of protein OPG57 (F13).
G243-1720 significantly inhibits the rdMPXVΔ96,158 infection in both HaCaT-96,158 and CV-1-96,158 cells with IC50 of 142 nM.
G243-1720 has an EC50 of 0.194 μM in Vero E6 cells infected with wild-type MPXV in plaque assays.
G243-1720 effectively inhibits VACV replication in these cell lines, with EC50 values ranging from 0.15 to 1.5 μM.
G243-1720 exhibits inhibitory effect on the replication of other orthopoxviruses like CPXV-BR, CPXV-E, CMLV, and RPXV, but not FPV (a member of the distantly related Avipoxvirus genus), HSV-1 (herpes simplex virus type 1), and the RNA viruses VSV (vesicular stomatitis virus) and SINV (Sindbis virus).
G243-1720 specifically inhibits the replication of orthopoxviruses.
G243-1720 via the intraperitoneal (i.p., 22.5 mg/kg) or intragastric (i.g., 45 mg/kg) route reduced the median viral titers from 5.48 logs in SCID mice infected with MPXV.
G243-1720 significantly inhibited infection at the post-entry or entire infection period but not during entry, impacts IEV formation and EEV release, which are critical for the long range spread of the orthopoxviruses.

物理化学性质&存储条件

分子量	437.98
分子式	C21H28ClN3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(azepane-1-carbonyl)-N-(2-chloro-4-methylphenyl)-1,2,5-trimethyl-1H-pyrrole-3-sulfonamide

参考文献

1. Chen J, et al. Nat Commun. 2025 Dec 15. doi: 10.1038/s41467-025-67487-w.

G243-1720

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G243-1720

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物理化学性质&存储条件

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