G-6599 | SMARCA2/A4 degrader | Probechem Biochemicals

Chemical Structure : G-6599

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G-6599 (G6599)

货号: PC-25679Not For Human Use, Lab Use Only.

G-6599 is a potent, specific small-molecule SMARCA2/A4 PROTAC degrader with DC50 of 17 pM and 57 pM respectively (SW1573 cells, 20 h, Dmax=95%), acting via the recruitment of FBXO22.

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生物&药学活性

G-6599 is a potent, specific small-molecule SMARCA2/A4 PROTAC degrader with DC50 of 17 pM and 57 pM respectively (SW1573 cells, 20 h, Dmax=95%), acting via the recruitment of FBXO22.

G-6599 is specific to SMARCA2/A4 and operates through the ubiquitin-proteasome pathway.

G-6599 induces cell growth inhibition comparable to A947 or FHD-286 based on studies in two SMARCA4-mutant models, NCI-H1944 and HCC515, wth no effect on cell growth in NCI-H522 cells that lack SMARCA2/A4.

FBXO22 ligase activity is required for SMARCA2/A4 degradation.

G-6599 acts as a monovalent degrader by covalently targeting FBXO22.

物理化学性质&存储条件

分子量	523.69
分子式	C31H37N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Phenol, 2-[6-amino-5-[8-[2-[4-(hexahydro-1H-azepin-1-yl)-1-butyn-1-yl]-4-pyridinyl]-3,8-diazabicyclo[3.2.1]oct-3-yl]-3-pyridazinyl]-

参考文献

1. Villemure E, et al. Nat Commun. 2025 Nov 3;16(1):9679.

G-6599 (G6599)

生物&药学活性

物理化学性质&存储条件

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G-6599 (G6599)

生物&药学活性

物理化学性质&存储条件

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