Fusicoccin (Fusicoccin A) | 14-3-3 modulator | Probechem Biochemicals

Chemical Structure : Fusicoccin

CAS No.: 20108-30-9

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Fusicoccin (Fusicoccin-A, Fusicoccin A, FC-A)

货号: PC-61233Not For Human Use, Lab Use Only.

Fusicoccin (Fusicoccin A) is a fungal pytotoxin and small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.

规格	价格	库存
1 mg	￥7980	In stock
2 mg	￥12800	In stock
5 mg		Get quote
10 mg		Get quote

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生物&药学活性

Fusicoccin (Fusicoccin A) is a fungal pytotoxin and small-molecule stabilizer of 14-3-3 protein-protein interactions that stabilizes the complex between 14-3-3 and the stress response regulator GCN1.
Fusicoccin (Fusicoccin A) induces GCN1 turnover and neurite outgrowth, stimulates axon growth in vitro and regeneration in vivo.
Fusicoccin (Fusicoccin A) stabilizes the interaction between 14-3-3 and CFTR by selectively interacting with a secondary binding motif of CFTR (pS753).

物理化学性质&存储条件

分子量	680.82
分子式	C36H56O12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	α-D-Glucopyranoside, (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propenyl)-, 3-acetate (9CI)

参考文献

1. Kaplan A, et al. Neuron. 2017 Mar 8;93(5):1082-1093.e5.

2. Stevers LM, et al. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61.

Fusicoccin (Fusicoccin-A, Fusicoccin A, FC-A)

生物&药学活性

物理化学性质&存储条件

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Fusicoccin (Fusicoccin-A, Fusicoccin A, FC-A)

生物&药学活性

物理化学性质&存储条件

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