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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Na-K-Cl Cotransporter (NKCC)-Furosemide
Furosemide

Chemical Structure : Furosemide

CAS No.: 54-31-9

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Furosemide

货号: PC-24730Not For Human Use, Lab Use Only.

Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter NKCC1 and NKCC2, is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors.

规格 价格 库存 数量
500 mg ￥290 In stock
1 g ￥450 In stock
2 g Get quote
5 g Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Furosemide is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC, encoded by SLC12A1 and SLC12A2) cotransporter NKCC1 and NKCC2, is also a GABAA receptors antagonist and displays 100-fold selectivity for α6-containing receptors than α1-containing receptors.

物理化学性质&存储条件

分子量 330.74
分子式 C12H11ClN2O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-chloro-2-((furan-2-ylmethyl)amino)-5-sulfamoylbenzoic acid

参考文献

1. C M Gillen, et al. J Biol Chem. 1996 Jul 5;271(27):16237-44.

2. S A Thompson, et al. Mol Pharmacol. 1999 Jun;55(6):993-9.

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