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首页-抗体和重组蛋白-Biosimilar Antibody-Fremanezumab
Fremanezumab

Chemical Structure : Fremanezumab

CAS No.: 1655501-53-3

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Fremanezumab (Anti-human CGRP mAb, human IgG2-Kappa; TEV48125)

货号: PC-Ab1047Not For Human Use, Lab Use Only.

Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene–related peptide (CGRP), a 37-amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab binds to the calcitonin gene-related peptide (CGRP) ligand, inhibiting the function of CGRP at its receptor, and thereby preventing migraine attacks..

规格 价格 库存 数量
1 mg ￥3580 In stock
5 mg ￥7580 In stock
10 mg ￥12800 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fremanezumab (TEV-48125) is a humanized IgG2a monoclonal antibody that selectively and potently binds to calcitonin gene–related peptide (CGRP), a 37-amino acid neuropeptide involved in central and peripheral pathophysiological events of migraine. Fremanezumab binds to the calcitonin gene-related peptide (CGRP) ligand, inhibiting the function of CGRP at its receptor, and thereby preventing migraine attacks.

物理化学性质&存储条件

分子量
分子式 Human IgG2-Kappa
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Fremanezumab; Ajovy; Fremanezumab-vfrm; TEV-48125; TEV48125; calcitonin gene-related peptide; CGRP.

参考文献

1. 1, Silberstein SD, et al. N Engl J Med. 2017 Nov 30;377(22):2113-2122.  2, Dodick DW, et al. JAMA. 2018 May 15;319(19):1999-2008. 3, Silberstein SD, et al. Expert Opin Biol Ther. 2019 Aug;19(8):763-771. 4, Urits I, et al. Pain Ther. 2020 Jun;9(1):195-215. 

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