Fosnetupitant chloride monohydrochloride | NK1R antagonist

Chemical Structure : Fosnetupitant chloride monohydrochloride

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Fosnetupitant chloride monohydrochloride (Pronetupitant)

货号: PC-27026Not For Human Use, Lab Use Only.

Fosnetupitant chloride monohydrochloride is a phosphorylated prodrug formulation of netupitant and selective neurokinin-1 receptor (NK1R) antagonist with pKi of 9.5, >1000-fold selective over NK3R.

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生物&药学活性

Fosnetupitant chloride monohydrochloride is a phosphorylated prodrug formulation of netupitant and selective neurokinin-1 receptor (NK1R) antagonist with pKi of 9.5, >1000-fold selective over NK3R.

物理化学性质&存储条件

分子量	761.52
分子式	C31H37Cl2F6N4O5P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5-(2-(3,5-Bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium chloride hydrochloride

参考文献

1. Inano H, et al. Biol Pharm Bull. 2024 Mar 25;47(3):692-697.

Fosnetupitant chloride monohydrochloride (Pronetupitant)

生物&药学活性

物理化学性质&存储条件

参考文献

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Fosnetupitant chloride monohydrochloride (Pronetupitant)

生物&药学活性

物理化学性质&存储条件

参考文献

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