Foselutoclax | BCL-xL inhibitor | Probechem Biochemicals

Chemical Structure : Foselutoclax

CAS No.: 2271269-01-1

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Foselutoclax (UBX1325)

货号: PC-24442Not For Human Use, Lab Use Only.

Foselutoclax (UBX1325) is a senolytic small-molecule inhibitor of BCL-xL.

规格	价格	库存
2 mg	￥3280	In stock
5 mg	￥5280	In stock
10 mg	￥7980	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

Foselutoclax (UBX1325) is a senolytic small-molecule inhibitor of BCL-xL.
UBX1325 is a phosphate pro-drug with improved aqueous solubility that releases the active parent molecule UBX0601.
UBX0601 prevented the formation of the antiapoptotic protein complexes through binding of BCL-xL and BCL-2 in biochemical competition binding assays with pKi of 8.6.
UBX0601 demonstrated potent target engagement (TE) through inhibition of the BCL-xL and BIM interaction.
UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR).

物理化学性质&存储条件

分子量	1159.69
分子式	C53H59ClF3N6O10PS3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-5-(4-chlorophenyl)-1-isopropyl-2-methyl-4-(3-(4-(4-((4-((1-(phenylthio)-4-(4-(phosphonooxy)piperidin-1-yl)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenyl)sulfonamido)phenyl)piperazin-1-yl)phenyl)-1H-pyrrole-3-carboxylic acid

参考文献

1. Crespo-Garcia S, et al. Nat Med. 2024 Feb;30(2):443-454.

Foselutoclax (UBX1325)

生物&药学活性

物理化学性质&存储条件

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Foselutoclax (UBX1325)

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物理化学性质&存储条件

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