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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Potassium Channel-Fluoxakalner
Fluoxakalner

Chemical Structure : Fluoxakalner

CAS No.:

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Fluoxakalner

货号: PC-27997Not For Human Use, Lab Use Only.

Fluoxakalner is a potent, selective Kv7.2/7.3 (KCNQ2/3) channel opener / activator with EC50 of 0.36 uM and 38.45 ± 5.80 mV leftward shift (ΔV1/2) in channel activation, produces robust antinociception in mouse pain models.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Fluoxakalner is a potent, selective Kv7.2/7.3 (KCNQ2/3) channel opener / activator with EC50 of 0.36 uM and 38.45 ± 5.80 mV leftward shift (ΔV1/2) in channel activation, produces robust antinociception in mouse pain models.

    物理化学性质&存储条件

    分子量 363.43
    分子式 C23H22FNO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-{4-[(4-fluorobenzyl)oxy]-2,6-dimethylphenyl}-2-phenylacetamide

    参考文献

    1. Wei Xiang, et al. Bioorg Chem. 2026 Sep 15:180:110099.

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