Fluoromethylcholine | TMA Lyase inhibitor | Probechem Biochemicals

Chemical Structure : Fluoromethylcholine

CAS No.: 459424-38-5

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Fluoromethylcholine (FMC)

货号: PC-25999Not For Human Use, Lab Use Only.

Fluoromethylcholine (FMC) is a highly potent TMA Lyase inhibitor in Escherichia coli (IC50 = 900 pM against Proteus mirabilis CutC/D) and in a polymicrobial human fecal culture (IC50 = 7.9 nM).

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50 mg	￥2780	In stock
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生物&药学活性

Fluoromethylcholine (FMC) is a highly potent TMA Lyase inhibitor in Escherichia coli (IC50= 0.9 nM against Proteus mirabilis CutC/D) and in a polymicrobial human fecal culture (IC50 = 7.9 nM).
Fluoromethylcholine (FMC) has been shown to be highly effective in vivo and completely inhibited plasma TMAO production in mice on a choline diet from a single oral dose (100 mg/kg).
Fluoromethylcholine (FMC) is also shown to be efficacious in an in vivo murine model of thrombus formation.

物理化学性质&存储条件

分子量	157.61
分子式	C5H13ClFNO
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethanaminium, N-(fluoromethyl)-2-hydroxy-N,N-dimethyl-, chloride (1:1)

参考文献

1. Roberts AB, et al. Nat Med. 2018 Sep;24(9):1407-1417.

Fluoromethylcholine (FMC)

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物理化学性质&存储条件

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Fluoromethylcholine (FMC)

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物理化学性质&存储条件

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