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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HSV-Fiacitabine
Fiacitabine

Chemical Structure : Fiacitabine

CAS No.: 69123-90-6

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Fiacitabine (NSC 382097, FIAC)

货号: PC-45855Not For Human Use, Lab Use Only.

Fiacitabine (NSC 382097, FIAC) is a synthesized pyrimidine analog that is a potent and selective anti-herpesvirus agent.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Fiacitabine (NSC 382097, FIAC) is a synthesized pyrimidine analog that is a potent and selective anti-herpesvirus agent.
Fiacitabine suppresses various strains of HSV1 and HSV2 with IC90 of 2.5 nM and 12.6 nM, respectively, shows minimal cytotoxicity; more potent than arabinosylcytosine, iododeoxyuridine, and arabinosyladenine.

物理化学性质&存储条件

分子量 371.1042
分子式 C9H11FIN3O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
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Solubility

DMSO: ≥ 37 mg/mL
Chemical Name/SMILES

2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-.beta.-D-arabinofuranosyl)-5-iodo-

参考文献

1. Lopez C, et al. Antimicrob Agents Chemother. 1980 May;17(5):803-6.

2. Allaudeen HS, et al. J Biol Chem. 1982 Oct 25;257(20):11879-82.

3. Schinazi RF, et al. Antimicrob Agents Chemother. 1983 Jul;24(1):95-103.

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