Ferritinophagy inhibitor 4k | Ferroptosis inhibitor | Probechem Biochemicals

Chemical Structure : Ferritinophagy inhibitor 4k

加入收藏

Ferritinophagy inhibitor 4k (Ferroptosis inhibitor, NCOA4-ferritin inhibior)

货号: PC-25428Not For Human Use, Lab Use Only.

Ferritinophagy inhibitor 4k is a specific inhibitor of ferritinophagy, disrupt the interaction of NCOA4 and ferritin, inhibits RSL3-induces ferroptosis with IC50 of 520 nM in HT-1080 cells.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Ferritinophagy inhibitor 4k is a specific inhibitor of ferritinophagy, disrupt the interaction of NCOA4 and ferritin, inhibits RSL3-induces ferroptosis with IC50 of 520 nM in HT-1080 cells.
Ferritinophagy inhibitor 4k reduces cellular free Fe2+ and protect cells from ferroptosis.
Ferritinophagy inhibitor 4k binds to NCOA4 (Kd=0.78 uM, MST assay) and impairs NCOA4-ferritin interaction.
Ferritinophagy inhibitor 4k reduces cellular ferrous iron level and upregulates the ferritin protein expression.
Ferritinophagy inhibitor 4k could effectively alleviate ConA-induced acute liver injury in a mouse model.

物理化学性质&存储条件

分子量	393.49
分子式	C27H23NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(tert-Butyl)-2,4-diphenylbenzofuro[2,3-b]pyridin-7-ol

参考文献

1. Zhang J, et al. J Med Chem. 2025 Aug 25. doi: 10.1021/acs.jmedchem.5c01942.

Ferritinophagy inhibitor 4k (Ferroptosis inhibitor, NCOA4-ferritin inhibior)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Ferritinophagy inhibitor 4k (Ferroptosis inhibitor, NCOA4-ferritin inhibior)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.