Fenobam

Chemical Structure : Fenobam

CAS No.: 57653-26-6

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货号: PC-26043Not For Human Use, Lab Use Only.

Fenobam is a potent, selective, BBB-penetrant and orally active mGluR5 antagonist with IC50 of 84 nM.

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生物&药学活性

Fenobam is a potent, selective, BBB-penetrant and orally active mGluR5 antagonist with IC50 of 84 nM.
Fenobam has Kd values of 54 nM and 31 nM on rat and human recombinant mGlu5 receptors, respectively.
Fenobam shows anxiolytic activity, inhibits self-administration behavior in mice, and induces apoptosis in cancer cells.

物理化学性质&存储条件

分子量	266.69
分子式	C11H11ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-Chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea

参考文献

1. Pecknold JC, et al. J Clin Psychopharmacol. 1982 Apr;2(2):129-33.

2. Porter RH, et al. J Pharmacol Exp Ther. 2005 Nov;315(2):711-21.

Fenobam

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Fenobam

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