Fedratinib (TG-101348, SAR302503) | JAK2 inhibitor | Probechem Biochemicals

Chemical Structure : Fedratinib

CAS No.: 936091-26-8

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Fedratinib (SAR302503, TG-101348)

货号: PC-42569Not For Human Use, Lab Use Only.

Fedratinib (TG-101348, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F.

规格	价格	库存
10 mg	￥480	In stock
50 mg	￥780	In stock
100 mg	￥1180	In stock
250 mg	￥1880	In stock
500 mg	￥2980	In stock
1 g		Get quote

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生物&药学活性

Fedratinib (TG-101348, SAR302503) is a potent, selective JAK2 inhibitor with IC50 of 3 nM for both wt JAK2 and JAK2 V617F.
TG-101348 also inhibits FLT3 (IC50=15 nM) and RET (IC50=48 nM) kinases, weakly inhibits JAK3 (IC50=168 nM), >35-fold selectivity over JAK1/3 and Tyk2.
TG-101348 shows therapeutic efficacy in a murine model of myeloproliferative disease induced by the JAK2V617F mutation.
TG-101348 also potently inhibits BRD4 with Kd of 168 nM.

物理化学性质&存储条件

分子量	524.6782
分子式	C27H36N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 42 mg/mL
Chemical Name/SMILES	Benzenesulfonamide, N-(1,1-dimethylethyl)-3-[[5-methyl-2-[[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]amino]-4-pyrimidinyl]amino]-

参考文献

1. Pardanani A, et al. Leukemia. 2007 Aug;21(8):1658-68.

2. Ciceri P, et al. Nat Chem Biol. 2014 Apr;10(4):305-12.

3. Wernig G, et al. Cancer Cell. 2008 Apr;13(4):311-20.

4. Geron I, et al. Cancer Cell. 2008 Apr;13(4):321-30.

Fedratinib (SAR302503, TG-101348)

生物&药学活性

物理化学性质&存储条件

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Fedratinib (SAR302503, TG-101348)

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物理化学性质&存储条件

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