Fascin inhibitor G2

Chemical Structure : Fascin inhibitor G2

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货号: PC-24547Not For Human Use, Lab Use Only.

Fascin inhibitor G2 is a small molecule inhibitor of Fascin (FSCN1), inhibits the actin-bundling function of fascin with IC50 of 5-8 uM, blocks tumour invasion and metastatic colonization.

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生物&药学活性

Fascin inhibitor G2 is a small molecule inhibitor of Fascin (FSCN1), inhibits the actin-bundling function of fascin with IC50 of 5-8 uM, blocks tumour invasion and metastatic colonization.
G2 inhibited the actin-bundling activity of fascin, but has no inhibitory effect on actin polymerization itself and the actin-bundling activity of L-plastin.
G2 directly interact with fascin with Kd of 5-20 uM.
G2 inhibits fascin function in cells and impairs the filopodial formation.
G2 could inhibit breast tumour cell migration specifically, with no effect on the growth of MDA-MB-231 and 4T1 tumour cells.
G2 is a potent inhibitor of 4T1 tumour cell metastasis from the mammary gland to the lungs, and the actin-bundling activity as well as filopodia are critical for tumour metastasis in mouse models.

物理化学性质&存储条件

分子量	385.35
分子式	C20H14F3N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1-(4-(trifluoromethyl)benzyl)-1H-indazol-3-yl)furan-2-carboxamide

参考文献

1. Huang FK, et al. Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization. Nat Commun. 2015;6:7465.