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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Factor Xa-Factor XIIa inhibitor F38
Factor XIIa inhibitor F38

Chemical Structure : Factor XIIa inhibitor F38

CAS No.:

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Factor XIIa inhibitor F38

货号: PC-26827Not For Human Use, Lab Use Only.

Factor XIIa inhibitor F38 is highly potent, selective and irreversible inhibitor of Factor XIIa (FXIIa) with IC50 of 2 nM, exhibits potent anticoagulant activity (EC1.5X=11 uM) and anti-inflammatory effects.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Factor XIIa inhibitor F38 is highly potent, selective and irreversible inhibitor of Factor XIIa (FXIIa) with IC50 of 2 nM, exhibits potent anticoagulant activity (EC1.5X=11 uM) and anti-inflammatory effects.

物理化学性质&存储条件

分子量 554.66
分子式 C30H34N8O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-(5-amino-3-(quinoxalin-2-yl)-1H-1,2,4-triazol-1-yl)(6-(3-(isopropyl(methyl)amino)pyrrolidin-1-yl)-2H,4H-spiro[benzo[b][1,4]dioxepine-3,1'-cyclopropan]-9-yl)methanone

参考文献

1. Geng L, et al. J Med Chem. 2026 May 14. doi: 10.1021/acs.jmedchem.6c01243.

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