FZ581 | sEH-P inhibitor | Probechem Biochemicals

Chemical Structure : FZ581

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FZ581 (FZ-581)

货号: PC-27819Not For Human Use, Lab Use Only.

FZ581 is a potent, pan-species inhibitor of soluble epoxide hydrolase (sEH) N-terminal phosphatase domain (sEH-P, sEH NTD) with IC50 of 59 and 490 nM for human and mouse sEH NTD, shows little to no activity against full-length sEH protein (sEH FL).

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生物&药学活性

FZ581 is a potent, pan-species inhibitor of soluble epoxide hydrolase (sEH) N-terminal phosphatase domain (sEH-P, sEH NTD) with IC50 of 59 and 490 nM for human and mouse sEH NTD, shows little to no activity against full-length sEH protein (sEH FL).
FZ581 shows high selectivity over the soluble epoxide hydrolase activity (sEH-H).
FZ581 does not exhibit significant binding toward other 9 tested phosphatases, as well as COX-1 and COX-2, lipid phosphate phosphatases (LPPs) LPP1-3.
FZ581 exhibits inhibitory activity across different species in vitro.
FZ581 shows dose-dependent inhibition of 1-oleyl monoacyl glycerol (sn1-18:1 MAG) formation through inhibition of recombinant mouse sEH.
FZ581 (1 mg/kg) demonstrated a significant increase of main sEH-P substrate levels without affecting plasma levels of sEH-H substrates in mice and rats.

物理化学性质&存储条件

分子量	466.67
分子式	C14H12ClIN2O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-2-((4-iodo-3-methylphenyl)amino)-5-sulfamoylbenzoic acid

参考文献

1. Zhu WF, et al. ACS Chem Biol. 2026 Aug 21;21(8):2053-2067.

FZ581 (FZ-581)

生物&药学活性

物理化学性质&存储条件

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FZ581 (FZ-581)

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物理化学性质&存储条件

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