FXIa inhibitor SB-01

Chemical Structure : FXIa inhibitor SB-01

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货号: PC-28280Not For Human Use, Lab Use Only.

FXIa inhibitor SB-01 is a potent, selective, allosteric inhibitor of human factor XIa (FXIa) inhibitor with IC50 of 130 nM, displays potent antithrombotic activity.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FXIa inhibitor SB-01 is a potent, selective, allosteric inhibitor of human factor XIa (FXIa) inhibitor with IC50 of 130 nM, displays potent antithrombotic activity.
SB-01 displays little to no activity (30-800-fold selective) against closest serine proteases FIIa, FXa, FIXa, FXIIa, and plasma kallikrein (P.Kal).
SB-01 inhibits FXIa activation of its natural protein substrate hFIX with IC50 of 150 nM.
SB-01 selectively prolongs activated partial thromboplastin time (APTT) over prothrombin time (PT), shows no impairment in FVII, FXIII, protein C (PrC), protein S (PrS), antithrombin (AT) or heparin cofactor II (HCII) in plasma.
SB-01 impacted all aspects of thrombus formation, including initiation of thrombus formation, rate of thrombus maturation and thrombus strength, in a concentration-dependent manner in human whole blood thromboelastography (TEG) studies.
SB-01 inhibits rodent arterial and venous thrombosis at doses of 6 and 3 mg/kg, respectively, preventing deep vein thrombosis in animals with lung cancer, does not significantly increase mouse tail bleeding time or blood loss.

物理化学性质&存储条件

分子量	2317.25
分子式	C48H24Na12O66S12
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	O=C(C1=CC(OS(=O)(O[Na])=O)=C(O)C(OS(=O)(O[Na])=O)=C1)O[C@@H]2[C@@H](OC(C3=CC(OS(=O)(O[Na])=O)=C(O)C(OS(=O)(O[Na])=O)=C3)=O)[C@@H](OC(C4=CC(OS(=O)(O[Na])=O)=C(O)C(OS(=O)(O[Na])=O)=C4)=O)[C@H](OC(C5=CC(OS(=O)(O[Na])=O)=C(O)C(OS(=O)(O[Na])=O)=C5)=O)[C@H](OC(C6=CC(OS(=O)(O[Na])=O)=C(O)C(OS(=O)(O[Na])=O)=C6)=O)[C@H]2OC(C7=CC(OS(=O)(O[Na])=O)=C(O)C(OS(=O)(O[Na])=O)=C7)=O

参考文献

1. Sharma C, et al. Blood Adv. 2026 Sep 18:bloodadvances.2026019983.