FXII900 | Factor XII inhibitor | Probechem Biochemicals

Chemical Structure : FXII900

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FXII900 (FXII-900)

货号: PC-28140Not For Human Use, Lab Use Only.

FXII900 is a potent, selective cyclic peptide coagulation factor XII (FXII) inhibitor with Ki of 0.37 nM and 0.45 nM for human and mouse FXIIa, >100,000-fold selectivity over other plasma proteases.

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生物&药学活性

FXII900 is a potent, selective cyclic peptide coagulation factor XII (FXII) inhibitor with Ki of 0.37 nM and 0.45 nM for human and mouse FXIIa, >100,000-fold selectivity over other plasma proteases.
FXII900 prolongs activated partial thromboplastin time (aPTT) in human plasma with an EC1.5x of 0.79 uM, does not affect prothrombin time (PT).
FXII900 prolongs the aPTT in plasma of all other species, namely mouse (EC1.5x = 2.9 μM), rabbit (EC1.5x = 0.102 μM), and pig (EC1.5x = 12.2 μM), wherein the potency varied significantly.
FXII900 inhibits ferric chloride-induced thrombosis in mice.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Jonas Wilbs, et al. Nat Commun. 2020 Aug 4;11(1):3890.

FXII900 (FXII-900)

生物&药学活性

物理化学性质&存储条件

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FXII900 (FXII-900)

生物&药学活性

物理化学性质&存储条件

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