FUT8 Inhibitor 40 (FUT8-IN-2)

Chemical Structure : FUT8 Inhibitor 40

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货号: PC-23122Not For Human Use, Lab Use Only.

FUT8 Inhibitor 40 (FUT8-IN-2) is a selective, cell-active inhibitor of α-1,6-fucosyltransferase (FUT8), inhibits FUT8 without inhibiting other FUTs.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FUT8 Inhibitor 40 (FUT8-IN-2) is a selective, cell-active inhibitor of α-1,6-fucosyltransferase (FUT8), inhibits FUT8 without inhibiting other FUTs.
FUT8 Inhibitor 40 (20 uM) significantly inhibited FUT8 activity in a cell-based assay, suppressed phosphorylation of EGFR in HepG2 hepatoma cells.
FUT8 Inhibitor 40 suppresses T-cell inflammatory responses, indicating a potential use as an immunomodulator.

物理化学性质&存储条件

分子量	529.08
分子式	C32H33ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(((6-chloro-1-((4-ethyl-2-phenylpiperazin-1-yl)methyl)naphthalen-2-yl)oxy)methyl)phenyl acetate

参考文献

1. Manabe Y, et al. Angew Chem Int Ed Engl. 2024 Sep 28:e202414682.