FTO inhibitor F97

Chemical Structure : FTO inhibitor F97

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货号: PC-24469Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

F97 is a specific small molecule inhibitor of fat mass and obesity-associated protein (FTO) with IC50 of 0.45 uM, selectively inhibits m6A demethylation by FTO rather than ALKBH5, and has minimal effect on m1A demethylation by ALKBH3.
F97 increases the protein levels of RARA and ASB2, while decreasing that of MYC in AML cell lines.
F97exhibits antileukemia activity in a xenograft mice model without significant side-effects.

物理化学性质&存储条件

分子量	393.51
分子式	C22H23N3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((2,6-dicyclopropyl-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl)amino)thiophene-2-carboxylic acid

参考文献

1. Deyan Zhang, et al. Eur J Med Chem. 2025 Feb 25:289:117444.