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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Farnesyl transferase (FTase)-FTI-277
FTI-277

Chemical Structure : FTI-277

CAS No.: 170006-73-2

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FTI-277 (FTI 277)

货号: PC-44766Not For Human Use, Lab Use Only.

FTI-277 is a peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.

规格 价格 库存 数量
2 mg ￥580 In stock
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg Get quote
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FTI-277 is a peptide mimetic of the C-terminal Cys-Val-Ile-Met of K-Ras4B that potently inhibits FTase (Farnesyltransferase) with IC50 of 0.5 nM.
FTI-277 highly selective for FTase over GGTase I (IC50 = 50 nM).
FTI-277 extremely potent (IC50=100 nM) at inhibiting H-Ras in whole cells.
FTI-277 blocks Ras oncogenic signaling by accumulating inactive Ras/Raf complexes in the cytoplasm.

物理化学性质&存储条件

分子量 447.614
分子式 C22H29N3O3S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

L-Methionine, N-[[5-[[(2R)-2-amino-3-mercaptopropyl]amino][1,1'-biphenyl]-2-yl]carbonyl]-, methyl ester

参考文献

1. Lerner EC, et al. J Biol Chem. 1995 Nov 10;270(45):26802-6.

2. Bernhard EJ, et al. Cancer Res. 1996 Apr 15;56(8):1727-30.

3. Bolick SC, et al. Leukemia. 2003 Feb;17(2):451-7.

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