FT206 (FT3951206) | USP28 inhibitor | Probechem Biochemicals

Chemical Structure : FT206

CAS No.: 2278274-34-1

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FT206 (FT-206, FT3951206, CRT0511973)

货号: PC-38173Not For Human Use, Lab Use Only.

FT206 (FT-206, FT3951206, CRT0511973) is a potent, selectivel inhibitor of USP28 with a remarkable USP28/25 selectivity.

规格	价格	库存
5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FT206 (FT-206, FT3951206, CRT0511973) is a potent, selectivel inhibitor of USP28 with a remarkable USP28/25 selectivity.
FT206 interferes with USP28/25 probe labelling (USP-ABP versus USP) in LSCC H520 cell extracts with EC50 of 0.3-1 uM.
USP28 inhibition causes apoptotic cell death of LSCC tumour cells.
FT206 also resulted in reduced Δp63, c-JUN, and c-MYC protein levels, causes dramatic regression of human LSCC xenograft tumours in vivo.

物理化学性质&存储条件

分子量	447.601
分子式	C25H29N5OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Thieno[2,3-b]pyridine-2-carboxamide, 3-amino-N-[(2S)-6-(3,8-diazabicyclo[3.2.1]oct-3-yl)-1,2,3,4-tetrahydro-2-naphthalenyl]-6-methyl-

参考文献

1. E Josue Ruiz, et al. Elife. 2021 Oct 12;10:e71596.

2. Jonathan D Wrigley, et al. ACS Chem Biol. 2017 Dec 15;12(12):3113-3125.

FT206 (FT-206, FT3951206, CRT0511973)

生物&药学活性

物理化学性质&存储条件

参考文献

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FT206 (FT-206, FT3951206, CRT0511973)

生物&药学活性

物理化学性质&存储条件

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