FRAG-i | Drp1 inhibitor | Probechem Biochemicals

Chemical Structure : FRAG-i

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FRAG-i (ZINC000079493999)

货号: PC-26856Not For Human Use, Lab Use Only.

FRAG-I is a small-molecule Drp1 inhibitor, binds the Drp1 GTPase domain with high affinity (Kd=732.4 nM), increases Drp1 thermal stability in recombinant and cellular assays.

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生物&药学活性

FRAG-I is a small-molecule Drp1 inhibitor, binds the Drp1 GTPase domain with high affinity (Kd=732.4 nM), increases Drp1 thermal stability in recombinant and cellular assays.
FRAG-i selectively suppresses mitochondrial fission in A549 lung carcinoma cells while sparing the fused networks of non-cancerous BEAS-2B epithelial cells.
FRAG-i preserves mitochondrial membrane potential, ATP levels, and redox balance without cytotoxicity, and modulates Drp1, MiD49, and Mfn2 expression in a context-dependent manner.

物理化学性质&存储条件

分子量	384.41
分子式	C17H16N6O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(3-(1H-indol-6-yl)-1,2,4-oxadiazol-5-yl)-N-(5-(methoxymethyl)-1,3,4-thiadiazol-2-yl)propanamide

参考文献

1. Şeyma Ateşoğlu, et al. Mitochondrion. 2026 May 14:102162.

FRAG-i (ZINC000079493999)

生物&药学活性

物理化学性质&存储条件

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FRAG-i (ZINC000079493999)

生物&药学活性

物理化学性质&存储条件

参考文献

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