FP1-24 | CK1γ inhibitor | Probechem Biochemicals

Chemical Structure : FP1-24

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FP1-24 (CK1γ Inhibitor 13)

货号: PC-25589Not For Human Use, Lab Use Only.

FP1-24 (CK1γ Inhibitor 13) is a potent and selective CK1γ inhibitor with IC50 of 5 nM, with 8- and 50-fold selective over CK1δ and CK1α respectively, and shows activity against GSK3β.

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生物&药学活性

FP1-24 (CK1γ Inhibitor 13) is a potent and selective CK1γ inhibitor with IC50 of 5 nM, with 8- and 50-fold selective over CK1δ and CK1α respectively, and shows activity against GSK3β.
FP1-24 (CK1γ Inhibitor 13) shows potency in the PO4-LRP6 and RKO-STF cell assay with IC50 of 0.2 uM and 0.254 uM respectively.
FP1-24 (CK1γ Inhibitor 13) (50 mg/kg, oral) inhibits CK1γ-mediated LRP6 phosphorylation in a human tumor xenograft mouse model.

物理化学性质&存储条件

分子量	385.37
分子式	C20H17F2N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-((3,4-difluorophenoxy)methyl)-5-methoxypyridin-4-yl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one

参考文献

1. Huang H, et al. ACS Med Chem Lett. 2012 Oct 18;3(12):1059-64.

2. Capener JL, et al. bioRxiv [Preprint]. 2025 Sep 16:2025.09.10.675406.

FP1-24 (CK1γ Inhibitor 13)

生物&药学活性

物理化学性质&存储条件

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FP1-24 (CK1γ Inhibitor 13)

生物&药学活性

物理化学性质&存储条件

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