Chemical Structure : FOXA1/2 inhibitor compound T
CAS No.:
886119-85-3
FOXA1/2 inhibitor compound T
货号: PC-25581Not For Human Use, Lab Use Only.
FOXA1/2 inhibitor compound T is a small molecule inhibitor of collaboration between FOXA1 and FOXA2, disrupt the FOXA1/2 function, binds to forkhead domain of FOXA1 of SPR KD of 100 uM.
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纯度 & COA & 质检文件 纯度:
>98% (HPLC)
生物&药学活性
FOXA1/2 inhibitor compound T is a small molecule inhibitor of collaboration between FOXA1 and FOXA2, disrupts the FOXA1/2 function, binds to forkhead domain of FOXA1 of SPR KD of 100 uM.
Compound T also reduced the luciferase reporter assay driven by the homolog FOXA3.
Compound T also disabled the FOXA1 and FOXA2 forkhead domain from binding to an immobilized double-strand DNA oligonucleotide by biolayer interferometry (BLI).
Compound T disrupted the binding of all three nucleotide sequences (i.e., C, PAL, and 2C) to either the forkhead domains of FOXA1, FOXA2, and FOXA1/FOXA2.
Compound T reduced FOXA1 chromatin binding in LNCaP cells, reduced FOXA1 and FOXA2 chromatin occupancy in PC3 cells.
Compound T selectively suppressed the clonogenic growth of cell lines expressing FOXA1 or FOXA1/2.
物理化学性质&存储条件
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分子量
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360.21
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分子式
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C14H11Cl2NO4S
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外观性状
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Solid
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CAS No.
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储存条件
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- 固体粉末
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-20°C 12 个月; 4°C 6 个月
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- 配置液
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-80°C 6 个月; -20°C 6 个月
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-((4,5-dichloro-2-methylphenyl)sulfonamido)benzoic acid
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参考文献
1. Formaggio N, et al. Cell Rep. 2025 Sep 26;44(10):116324.
