FOBISIN101 | 14-3-3 inhibitor | Probechem Biochemicals

Chemical Structure : FOBISIN101

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FOBISIN101 (FOBISIN 101)

货号: PC-62030Not For Human Use, Lab Use Only.

FOBISIN101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.

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生物&药学活性

FOBISIN101 is a small molecule 14-3-3 protein-protein interaction inhibitor with IC50 of 9.3 and 16.4 uM for the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively.
FOBISIN101 effectively blocks the ability of all seven 14-3-3 isoforms to stimulate exoenzyme S (ExoS) ADP-ribosyltransferase (IC50=6-19 uM in a functional assay).
FOBISIN101 also blocked the binding of 14-3-3 with Raf-1 and proline-rich AKT substrate, PRAS40.

物理化学性质&存储条件

分子量	461.209
分子式	C15H11N3Na3O8P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[(2Z)-2-[4-formyl-6-methyl-5-oxo-3-(phosphonatooxymethyl)pyridin-2-ylidene]hydrazinyl]benzoate trisodium salt

参考文献

1. Zhao J, et al. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16212-6.

2. Du Y, et al. J Biomol Screen. 2006 Apr;11(3):269-76.

3. Fu H, et al. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2320-4.

FOBISIN101 (FOBISIN 101)

生物&药学活性

物理化学性质&存储条件

参考文献

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FOBISIN101 (FOBISIN 101)

生物&药学活性

物理化学性质&存储条件

参考文献

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