FM029 | FOXP3-T-bet stabliezer | Probechem Biochemicals

Chemical Structure : FM029

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FM029 (FM-029)

货号: PC-28145Not For Human Use, Lab Use Only.

FM029 is a direct FOXP3 targeting small molecule that binds to FOXP3 (SPR KD=1.13 uM), stabilizes the FOXP3-T-bet interaction to represses T-bet-driven IFN-γ production.

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生物&药学活性

FM029 is a direct FOXP3 targeting small molecule that binds to FOXP3 (SPR KD=1.13 uM), stabilizes the FOXP3-T-bet interaction to represses T-bet-driven IFN-γ production.
FM029 binds mouse FOXP3WT protein and mouse FOXP3V408M protein, with KD values of 0.96 μM and 0.94 μM, respectively.
FM029 significantly reduced IFN-γ production in V408M iTregs but not in WT iTregs, does not suppress IFN-γ production in FOXP3-deficient Tconv cells.
FM029 markedly enhanced the ability of both WT and V408M Tregs to suppress IFN-γ production by Tconv cells.
FM029 alleviates IFN-γ+ Treg-driven tissue inflammation in V408M mice.
FM029 restrains Treg-derived IFN-γ production and ameliorates colitis.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Weiqi Zhang, et al. Cell Mol Immunol. 2026 Sep 3. doi: 10.1038/s41423-026-01468-x.

FM029 (FM-029)

生物&药学活性

物理化学性质&存储条件

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FM029 (FM-029)

生物&药学活性

物理化学性质&存储条件

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