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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -FLS-359
FLS-359

Chemical Structure : FLS-359

CAS No.: 2309398-79-4

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FLS-359 (FLS359, FLS 359)

货号: PC-21014Not For Human Use, Lab Use Only.

FLS-359 (FLS359) is a selective, allosteric inhibitor of sirtuin 2 (SIRT2) deacetylase activity with IC50 of 3 uM, shows no activity against SIRT1 and SIRT3, exhibits broad-spectrum antiviral activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    FLS-359 (FLS359) is a selective, allosteric inhibitor of sirtuin 2 (SIRT2) deacetylase activity with IC50 of 3 uM, shows no activity against SIRT1 and SIRT3, exhibits broad-spectrum antiviral activity.
    FLS-359 is not competitive with NAD+, FLS-359 is substrate selective, inhibiting deacetylation but not demyristoylation.
    FLS-359 induces degradation of c-Myc protein in MDA-MB-231 breast adenocarcinoma cells.
    FLS-359 binds selectively to SIRT2 and induces an allosteric rearrangement of the active site, reducing the rate of deacetylation.
    FLS-359 shows activity against multiple RNA and DNA viruses in cultured cells (SARS-CoV-2/human Calu3, IC50=0.3 uM; HCMV/human MRC-5, IC50=0.5 uM).
    FLS-359 markedly reduces EBV lytic activation in Akata cells, inhibitsthe accumulation of viral immediate-early (BZLF1), early (BMRF1), and late (BLLF1) mRNAs.
    FLS-359 inhibits HCMV spread in diploid fibroblasts, inhibits the accumulation of intracellular HCMV RNAs and DNA and reduces the infectivity of virus progeny.
    FLS-359 (50 mg/kg, p.o., b.i.d.) inhibits HCMV infection in humanized models of HCMV infection.

    物理化学性质&存储条件

    分子量 466.61
    分子式 C27H26N6S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(4-(1H-pyrazol-1-yl)benzyl)-2-(7-(2,4-dimethyl-1H-imidazol-1-yl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole

    参考文献

    1. Kathryn L Roche, et al. J Clin Invest. 2023 Jun 15;133(12):e158978.

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