FLIX5 | EPLIN inhibitor | Probechem Biochemicals

Chemical Structure : FLIX5

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FLIX5 (NSC328403, 4-Formylcolchicine)

货号: PC-25248Not For Human Use, Lab Use Only.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FLIX5 (NSC328403, 4-Formylcolchicine) is a specific small molecule targeting EPLIN (Epithelial Protein Lost In Neoplasm), binds stably to EPLIN and exhibits broad cytotoxicity against both neuroblastoma and medulloblastoma cells, primarily by triggering apoptosis.
FLIX5 impairs mitochondrial function and increases the dependency of neuroblastoma cells on lipid metabolism.
FLIX5 prefers to bind to EPLIN compared to SRRD and SLTM.
FLIX5 enhances the cholesterol dependency of neuroblastoma cells under conditions where mitochondrial function is impaired.
FLIX5 induces p53-independent induction of apoptosis.
FLIX5 synergizes with conventional chemotherapy in the treatment of neuroblastoma, shows selectivity between normal and cancer cells.

物理化学性质&存储条件

分子量	427.45
分子式	C23H25NO7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Acetamide, N-[(7S)-4-formyl-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-

参考文献

1. Lindell E, et al. Cell Death Dis. 2025 Jul 23;16(1):554.

FLIX5 (NSC328403, 4-Formylcolchicine)

生物&药学活性

物理化学性质&存储条件

参考文献

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FLIX5 (NSC328403, 4-Formylcolchicine)

生物&药学活性

物理化学性质&存储条件

参考文献

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