FLIPinBγ

Chemical Structure : FLIPinBγ

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货号: PC-23805Not For Human Use, Lab Use Only.

FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.

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生物&药学活性

FLIPinBγ is a first-in class, specific small molecule inhibitor of c-FLIPL in the caspase-8/c-FLIPL heterodimer, promotes CD95L- and TRAIL-mediated loss of cell viability and cell death.
FLIPinBγ does not act via modulating the protein level of c-FLIPL.
FLIPinBγ acts via enhancement of caspase-8 activity at the DISC.
c-FLIPL, the long isoform of c-FLIP, is a DED-containing protein and a key regulator of the extrinsic apoptosis pathway. DISC comprises DR, FADD, procaspase-8/10 and c-FLIPL/S/R proteins, DISC serves as a platform for procaspase-8 activation, which takes place upon its oligomerization in the death effector domain (DED)-filaments, initiating the apoptotic destruction of the cell.

物理化学性质&存储条件

分子量	516.57
分子式	C27H24N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(4-(pyridin-4-yl)benzamido)ethyl 3-(N-(pyridin-3-ylmethyl)sulfamoyl)benzoate

参考文献

1. Hillert LK, et al. Cell Death Differ. 2020 Jul;27(7):2117-2130.

FLIPinBγ

生物&药学活性

物理化学性质&存储条件

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FLIPinBγ

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