FIN56 | Ferroptosis inducer | Probechem Biochemicals

Chemical Structure : FIN56

CAS No.: 1083162-61-1

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FIN56 (FIN-56, Ferroptosis inducer)

货号: PC-60374Not For Human Use, Lab Use Only.

FIN56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4.

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10 mg	￥980	In stock
25 mg	￥1680	In stock
50 mg	￥2680	In stock
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生物&药学活性

FIN56 is a potent and specific Ferroptosis inducer that promotes the degradation of the lipid-repair enzyme GPX4.
FIN56 also binds to and activates squalene synthase, an enzyme involved in the cholesterol synthesis, to suppress non-steroidogenic metabolites-most likely coenzyme Q10.
FIN56 the mechanism involves two distinct pathways: one pathway is degradation of GPX4, which requires the enzymatic activity of ACC.
FIN56 has the other pathway is activation of SQS, which leads to coenzyme Q10 depletion.

物理化学性质&存储条件

分子量	517.66
分子式	C25H31N3O5S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N2,N7-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

参考文献

1. Shimada K, et al. Nat Chem Biol. 2016 Jul;12(7):497-503.

FIN56 (FIN-56, Ferroptosis inducer)

生物&药学活性

物理化学性质&存储条件

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FIN56 (FIN-56, Ferroptosis inducer)

生物&药学活性

物理化学性质&存储条件

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