FICD inhibitor C22

Chemical Structure : FICD inhibitor C22

CAS No.: 2256089-90-2

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货号: PC-24463Not For Human Use, Lab Use Only.

规格	价格	库存
5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4880	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

FICD inhibitor C22 is a specific, cell-permeable inhihitor of the AMP transferase FICD, significantly inhibits endogenous FICD-mediated BiP AMPylation (IC50=7.27 uM) while weakly inhibiting BiP deAMPylation.
C22 may bind to the dimer interface of endogenous FICD and prevent the dimeric deAMPylase-competent FICD from adopting an AMPylase-competent conformation.
C22 is noncytotoxic that do not trigger the UPRER and are effective against pathogenic FICD mutants in vitro.
C22 improves proinsulin folding and secretion in pancreatic β cells by reducing basal BiP AMPylation.
Human FICD, also referred to as Huntingtin yeast-interacting partner E (HYPE), localizes to the ER lumen and is N-glycosylated on Asn275.

物理化学性质&存储条件

分子量	663.07
分子式	C22H14Cl2I2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

参考文献

1. Chatterjee BK, et al. ACS Chem Biol. 2025 Mar 4. doi: 10.1021/acschembio.4c00847.