FGH10019

Chemical Structure : FGH10019

CAS No.: 1046045-61-7

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货号: PC-24553Not For Human Use, Lab Use Only.

FGH10019 is a specific small molecule inhibitor of sterol regulatory element-binding protein (SREBP) with IC50 of 0.7 uM in SREBP-responsive reporter gene assays.

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5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
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100 mg		Get quote

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生物&药学活性

FGH10019 is a specific small molecule inhibitor of sterol regulatory element-binding protein (SREBP) with IC50 of 0.7 uM in SREBP-responsive reporter gene assays.
FGH10019 is comparable to the potency of an endogenous inhibitor, 25- hydroxycholesterol, which has an IC50 value of 0.3 uM.
FGH10019 decreases the percentage of the mature form of SREBP-2 at lower concentrations (IC50=1 uM) than treatment with Fatostatin (Cat# PC-22262).
FGH10019 (1-20 uM) decreases the expression of SREBP-responsive genes in DU145 cells.
FGH10019 is orally available in mice.

物理化学性质&存储条件

分子量	373.49
分子式	C18H19N3O2S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(2-(2-propylpyridin-4-yl)thiazol-4-yl)phenyl)methanesulfonamide

参考文献

1. Kamisuki S, et al. J Med Chem. 2011 Jul 14;54(13):4923-7.

FGH10019

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