FG-2101 | LpxC inhibitor | Probechem Biochemicals

Chemical Structure : FG-2101

CAS No.: 2919723-66-1

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FG-2101 (FG2101)

货号: PC-24393Not For Human Use, Lab Use Only.

FG-2101 (FG2101) is a potent, in vivo active, non-hydroxamate inhibitor of LpxC with IC50 of 1 nM, exhibits exquisite selectivity over other bacterial and human metalloenzymes (>10,000-fold).

规格	价格	库存
2 mg	￥2880	In stock
5 mg	￥4880	In stock
10 mg	￥7880	In stock
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100 mg		Get quote

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生物&药学活性

FG-2101 (FG2101) is a potent, in vivo active, non-hydroxamate inhibitor of LpxC with IC50 of 1 nM, exhibits exquisite selectivity over other bacterial and human metalloenzymes (>10,000-fold).
FG-2101 exhibits potent activity against most Enterobacterales, including Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter, Citrobacter, Salmonella, Shigella, and Campylobacter spp., along with biothreat pathogens Francisella tularensis and Yersinia pestis.
FG-2101 is efficacious in multiple animal models of Gram-negative infection including drug-resistant strains via IV and oral routes of administration, does not display preclinical toxicity observed with previous hydroxamate-based inhibitors.

物理化学性质&存储条件

分子量	589.59
分子式	C30H32N5O6P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-Azetidinecarbonitrile, 1-[(2S)-3-[1,6-dihydro-6-oxo-5-(phosphonooxy)-4-pyrimidinyl]-2-[4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]phenyl]propyl]-

参考文献

1. Patent WO2023055686 A1.

FG-2101 (FG2101)

生物&药学活性

物理化学性质&存储条件

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FG-2101 (FG2101)

生物&药学活性

物理化学性质&存储条件

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