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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-FG-0041
FG-0041

Chemical Structure : FG-0041

CAS No.: 53946-49-9

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FG-0041 (FG0041)

货号: PC-21729Not For Human Use, Lab Use Only.

FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.

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2 mg ￥2180 In stock
5 mg ￥3580 In stock
10 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

FG-0041 (FG0041) is a small molecule inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 of 2 uM for collagen prolyl hydroxylase.
FG-0041 in low micromolar concentrations led to the dose-dependent accumulation of HIF1α in a variety of mammalian cells, accumulated transcriptionally active HIF.
FG-0041 also inhibits asparagine hydroxylation. FG-0041 was shown earlier to preserve left ventricular function in a rodent model of myocardial infarction.

物理化学性质&存储条件

分子量 240.22
分子式 C13H8N2O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-oxo-1,4-dihydro-1,10-phenanthroline-3-carboxylic acid

参考文献

1. Mircea Ivan, et al. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13459-64.

2. Nwogu J I, et al. Circulation. 2001;104:2216–2221.

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